In Vitro Antibacterial, Antifungal, Antibiofilm, Antioxidant, and Anticancer Properties of Isosteviol Isolated from Endangered Medicinal Plant Pittosporum tetraspermum
Identifieur interne : 000833 ( Main/Exploration ); précédent : 000832; suivant : 000834In Vitro Antibacterial, Antifungal, Antibiofilm, Antioxidant, and Anticancer Properties of Isosteviol Isolated from Endangered Medicinal Plant Pittosporum tetraspermum
Auteurs : Naif Abdullah Al-Dhabi [Arabie saoudite] ; Mariadhas Valan Arasu [Arabie saoudite] ; Thankappan Sarasam Rejiniemon [Inde]Source :
- Evidence-based Complementary and Alternative Medicine : eCAM [ 1741-427X ] ; 2015.
Abstract
This study aimed to investigate the
Url:
DOI: 10.1155/2015/164261
PubMed: 26101532
PubMed Central: 4460244
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en"><italic>In Vitro</italic> Antibacterial, Antifungal, Antibiofilm, Antioxidant, and Anticancer Properties of Isosteviol Isolated from Endangered Medicinal Plant <italic>Pittosporum tetraspermum</italic></title><author><name sortKey="Abdullah Al Dhabi, Naif" sort="Abdullah Al Dhabi, Naif" uniqKey="Abdullah Al Dhabi N" first="Naif" last="Abdullah Al-Dhabi">Naif Abdullah Al-Dhabi</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Botany and Microbiology, Addiriyah Chair for Environmental Studies, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Department of Botany and Microbiology, Addiriyah Chair for Environmental Studies, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451</wicri:regionArea><wicri:noRegion>Riyadh 11451</wicri:noRegion></affiliation></author><author><name sortKey="Valan Arasu, Mariadhas" sort="Valan Arasu, Mariadhas" uniqKey="Valan Arasu M" first="Mariadhas" last="Valan Arasu">Mariadhas Valan Arasu</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Botany and Microbiology, Addiriyah Chair for Environmental Studies, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Department of Botany and Microbiology, Addiriyah Chair for Environmental Studies, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451</wicri:regionArea><wicri:noRegion>Riyadh 11451</wicri:noRegion></affiliation></author><author><name sortKey="Rejiniemon, Thankappan Sarasam" sort="Rejiniemon, Thankappan Sarasam" uniqKey="Rejiniemon T" first="Thankappan Sarasam" last="Rejiniemon">Thankappan Sarasam Rejiniemon</name><affiliation wicri:level="1"><nlm:aff id="I2">Department of Botany and Biotechnology, AJ College of Science and Technology, Thonnakkal, Trivandrum, Kerala 695 317, India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Botany and Biotechnology, AJ College of Science and Technology, Thonnakkal, Trivandrum, Kerala 695 317</wicri:regionArea><wicri:noRegion>Kerala 695 317</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26101532</idno><idno type="pmc">4460244</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4460244</idno><idno type="RBID">PMC:4460244</idno><idno type="doi">10.1155/2015/164261</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">000050</idno><idno type="wicri:Area/Pmc/Curation">000050</idno><idno type="wicri:Area/Pmc/Checkpoint">000638</idno><idno type="wicri:Area/Ncbi/Merge">001B87</idno><idno type="wicri:Area/Ncbi/Curation">001B87</idno><idno type="wicri:Area/Ncbi/Checkpoint">001B87</idno><idno type="wicri:Area/Main/Merge">000833</idno><idno type="wicri:Area/Main/Curation">000833</idno><idno type="wicri:Area/Main/Exploration">000833</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main"><italic>In Vitro</italic> Antibacterial, Antifungal, Antibiofilm, Antioxidant, and Anticancer Properties of Isosteviol Isolated from Endangered Medicinal Plant <italic>Pittosporum tetraspermum</italic></title><author><name sortKey="Abdullah Al Dhabi, Naif" sort="Abdullah Al Dhabi, Naif" uniqKey="Abdullah Al Dhabi N" first="Naif" last="Abdullah Al-Dhabi">Naif Abdullah Al-Dhabi</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Botany and Microbiology, Addiriyah Chair for Environmental Studies, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Department of Botany and Microbiology, Addiriyah Chair for Environmental Studies, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451</wicri:regionArea><wicri:noRegion>Riyadh 11451</wicri:noRegion></affiliation></author><author><name sortKey="Valan Arasu, Mariadhas" sort="Valan Arasu, Mariadhas" uniqKey="Valan Arasu M" first="Mariadhas" last="Valan Arasu">Mariadhas Valan Arasu</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Botany and Microbiology, Addiriyah Chair for Environmental Studies, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Department of Botany and Microbiology, Addiriyah Chair for Environmental Studies, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451</wicri:regionArea><wicri:noRegion>Riyadh 11451</wicri:noRegion></affiliation></author><author><name sortKey="Rejiniemon, Thankappan Sarasam" sort="Rejiniemon, Thankappan Sarasam" uniqKey="Rejiniemon T" first="Thankappan Sarasam" last="Rejiniemon">Thankappan Sarasam Rejiniemon</name><affiliation wicri:level="1"><nlm:aff id="I2">Department of Botany and Biotechnology, AJ College of Science and Technology, Thonnakkal, Trivandrum, Kerala 695 317, India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Botany and Biotechnology, AJ College of Science and Technology, Thonnakkal, Trivandrum, Kerala 695 317</wicri:regionArea><wicri:noRegion>Kerala 695 317</wicri:noRegion></affiliation></author></analytic><series><title level="j">Evidence-based Complementary and Alternative Medicine : eCAM</title><idno type="ISSN">1741-427X</idno><idno type="eISSN">1741-4288</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>This study aimed to investigate the <italic>in vitro</italic> antibacterial, antifungal, antibiofilm, antioxidant, and anticancer properties of isosteviol isolated from endangered medicinal plant <italic>Pittosporum tetraspermum</italic>. Pure compound was obtained and characterized by column chromatography followed by <sup>1</sup>H NMR, <sup>13</sup>C NMR, IR, and mass spectral analysis. The antimicrobial activities of the compound were assessed by the broth microdilution method and the antioxidant properties were determined using reducing ability assay, DPPH scavenging assay, hydroxyl radical scavenging activity, and superoxide radical scavenging assay. Anticancer study was evaluated by following MTT assay. Column purification and spectrocopical analysis lead to identifying isosteviol from the crude ethyl acetate extract. The compound exhibited significant activity against bacteria such as <italic>Staphylococcus epidermidis</italic> (125 <italic>µ</italic>g/mL), <italic>Staphylococcus aureus</italic> (125 <italic>µ</italic>g/mL), and <italic>Klebsiella pneumoniae</italic> (62.5 <italic>µ</italic>g/mL). The MIC of the compound against <italic>Candida albicans</italic>, <italic>Aspergillus niger</italic>, and <italic>Trichophyton mentagrophytes</italic> was 62.5, 125, and 500 <italic>µ</italic>g/mL, respectively. The compound showed comparatively better antibiofilm activity against <italic>E. coli</italic>, <italic>S. typhi</italic>, and <italic>P. aeruginosa</italic>. Furthermore, it exhibited good antioxidant properties. Anticancer properties of the compound against Vero and MCF7 cell lines were its advantage. Novel isosteviol would be useful to reduce the infectious diseases caused by pathogenic microorganisms or slow the progress of various oxidative stress-related diseases.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Namita, P" uniqKey="Namita P">P. Namita</name></author><author><name sortKey="Mukesh, R" uniqKey="Mukesh R">R. 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Park</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mann, J" uniqKey="Mann J">J. Mann</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Arabie saoudite</li><li>Inde</li></country></list><tree><country name="Arabie saoudite"><noRegion><name sortKey="Abdullah Al Dhabi, Naif" sort="Abdullah Al Dhabi, Naif" uniqKey="Abdullah Al Dhabi N" first="Naif" last="Abdullah Al-Dhabi">Naif Abdullah Al-Dhabi</name></noRegion><name sortKey="Valan Arasu, Mariadhas" sort="Valan Arasu, Mariadhas" uniqKey="Valan Arasu M" first="Mariadhas" last="Valan Arasu">Mariadhas Valan Arasu</name></country><country name="Inde"><noRegion><name sortKey="Rejiniemon, Thankappan Sarasam" sort="Rejiniemon, Thankappan Sarasam" uniqKey="Rejiniemon T" first="Thankappan Sarasam" last="Rejiniemon">Thankappan Sarasam Rejiniemon</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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